Nano Vs. Dehydratech
DehyrdaTECH™ does not simply make things smaller – we make things “simply” effective. We believe in performance.
NANOEMULSION vs. DEHYDRATECH™
“DehyrdaTECH™ does not simply make things smaller – we make things simply effective”. DehydraTECH™ introduces cannabidiol molecules into your system faster and cleaner!
Cannabidiol (cannabinoid or hemp oil) is hydrophobic (water opposing) and this presents a great problem in introducing it to human physiology. Oral delivery of many hydrophobic ingredients such as cannabinoid is challenging to formulators due to their poor solubility and thus bioavailability. Limitations in solubility leads to less solubilization in the gastrointestinal tract and absorption by the body. Many solutions have been used, in an attempt, to overcome this, including the use of surfactants, lipids, permeation enhancers, micronization, salt formulation, cyclodextrins, nanoparticles and solid dispersions. The latest trend in cannabinoid delivery methods is “nanoemulsion”. Nano technology essentially seeks to reduce the size of the cannabinoid particle and, when combined with an emulsion, enhances dissolubility. But does it enhance bioavailability?
DehydraTECH™ is an elegant technology with Self Emulsifying Drug Delivery System (SEDDS) properties that can be applied to the cannabidiol molecule and its derivatives. This system is used in high-end pharmaceutical biodelivery processes. Self-emulsifying drug delivery systems are a proven scientific means of enhancing oral bioavailability of poorly soluble drugs.
The emulsion of choice for nano technology is usually a medium chain triglyceride (MCT), and when the nano cannabinoid and emulsion combination break apart in the stomach, the cannabinoid is directed to the liver. The liver metabolizes between 35% to 45% of the cannabinoid greatly affecting bioavailability. Some nano technologies use Polysorbate 80, an emulsifier that has serious and known adverse effects on the mucous lining of the stomach among other undesirable side effects.
Nano technology creates smaller particles in the manufacturing process, but once in the stomach these particles recombine to randomly different sizes. Additionally, nano-scale particles may create significant health concerns in areas of the body not designed for such wholesale particle size reduction. Nanoemulsion is built around reducing the size of the cannabinoid molecule before combining it with the emulsifier. DehydraTECH™ technology is sent to the lymphatic system and straight into the bloodstream without metabolic degradation. And this happens very rapidly: clinical studies have shown DehydraTECH™’s onset is comparable to vaping, with cannabinoid measurable in the bloodstream within two minutes of ingestion.
In Nanoemulsion, the value and benefits of size relative to human physiology is not quantified in any clinical or laboratory study. Efficacy is affected by diet, and dosing is thus imprecise. DehydraTECH™ has been clinically proven in independent studies to effectively enter the bloodstream without metabolic degradation by the liver. Dosing is precise: virtually all of the cannabinoid enters the bloodstream and becomes available to the endocannabinoid system. Further, Nanoemulsion can fall out of suspension and is not evenly dispersed in the form factor. The nano particles of cannabinoid reduced in the Nanoemulsion process recombine and defeat the purpose of micronization. The body’s physiological processes endemic to bioabsorption are not addressed by merely changing particle size.
DehydraTECH™ remains in suspension in the form factor (for more than two years in shelf-life studies). The cannabinoid becomes one with the substrate until it is released in the body to the bloodstream. Nanoemulsion formulas require flavoring, added sweeteners, and other agents to mask cannabinoid’s unpleasant organoleptics. DehydraTECH™ eliminates any unpleasant taste by enrobing the cannabinoid within the chosen substrate. Nothing more is required. The advantages of DehydraTECH™ include: Enhanced oral biodelivery, the ability to reduce dosage without reducing efficacy, more consistent absorption and protection of the cannabidiol from the hostile environment in the gastrointestinal tract. DehydraTECH™ introduces cannabinoid into your system faster and cleaner!
